Comparative Controlled Study of Preventive Effect of Combinations of Ketamine and Metoclopramide vs Ketamine and Paracetamol on Postoperative Pain

In this study, we compared the effects combinations of ketamine and paracetamol with ketamine and metoclopramide on postoperative pain and their effects on surgical complications. Then, better method for reducing pain and complications was referenced.
In a clinical trial study, 102 candidates for laparoscopic surgery under general anesthesia divided into three equal groups of ketamine and metoclopramide, ketamine and paracetamol, and control. In the first group, 0.5 mg/kg ketamine and 0.1 mg/kg metoclopramide, in the second group, 0.5 mg/kg ketamine and 1 g paracetamol, and in the third group, normal saline were injected. Patients’ systolic and diastolic blood pressures and heart rates in all three groups were measured and recorded every 15 minutes. Then, the effects of these two drug combinations on postoperative pain and some other complications were studied and compared between the three groups.
Findings: Average pain intensity was significantly different among the three treated groups (P Combination of ketamine and paracetamol is more favorable because of significant decrease in postoperative pain.