Evaluation of Carbomer, CMC and HPMC on Dissolution and Bioadhesion of buccoadhesive Cinnamaldehyde Tablets

Background and Transmucosal drug delivery unlike oral drug delivery has some advantages including deletion of first past effect and prevention of drug removal in gastro-intestinal tract and enzymatic flora. This study aimed at evaluating the effect of CMC, cerbomer and HPMC on Cinnamaldehyde release from formulation matrix and mucoadhesion of these formulations.
In this experimental research, nine formulations were selected and several tests including flowability, compressibility, hardness, assay, friability, swelling, and bioadhesive force were done.
According to the study, the angles of repose for all formulations were between 20.06±1.67 and 31.93±2.44. In addition, F5 and F6 had the most regular drug release patterns while F8 and F9 were found to have the fastest drug release. Maximum bioadhesive strength was observed in F8 and F9 but the minimum was observed in F3 and F4.
Drug delivery studies are of great importance, particularly for the drugs that do not have therapeutic efficacy in other routs of administration. According to current findings, HPMC induces the best formulation for transmucosal drug delivery.