Antinociceptive and Anti-inflammatory effects of Hydroalcoholic extract of aerial parts of Thymus carmanicus in male mice

Differentspecies of Thymusare capable of producing various pharmacological effects. The present paper aimsto investigate the analgesic and anti-inflammatory effects of hydro-alcoholic extract of areal parts of Thymus Carmanicus Jalas.In this experimental research, using the formalin,writhing and tail immersion tests, anti-inflammatory effectswere studied in micebyxylene-induced ear edemaand mercury immersion methods. Male NMRI mice weighing 20-25g were dividedinto five groups: negative control, positive control and three experimental groups, being injectedintraperitoneally by 250, 500 and 1000 mg/kg of hydroalcoholic extracts of Thymus carmanicus. The most effective dose of the extract was selected for the possible involvement of opioidergic systems. Animalsubjects were studied by pretreatment of opioid antagonist, naloxone. The data were analyzed throughANOVA and Tukey's test.Results indicated that in the formalin test, thedoses of 500 and 1000 mg/kg of theextract significantly reduced the score of analgesic in experimental groups(P