Antioxidant, Antiglycation and Anti-Hyperlipidemic Effects of Trigonella foenum and Cinnamon in Type 2 Diabetic Rats

Diabetes is recognized as a common metabolic disorder, which is treated by different medicines.
The aim of this study was to study the effect of Trigonella foenum and Cinnamon on glycation, some biochemical factors, liver histology and cholesterol 7-alpha hydroxylase activity in type 2 diabetic rats.
Antiglycation and antioxidant ability were determined in vitro. Male Wistar diabetic rats were treated by 2 and 8% of Cinnamon (w/w) and Trigonella foenum. Biochemical factors and liver enzymes were measured using enzymatic spectrophotometric methods. Lipase and cholesterol 7-alpha hydroxylase activity were determined. Liver lipid, antioxidant and morphological change were assessed.
Different concentrations of these plants (0.032, 0.065, 0.125, 0.25, 0.5 and 1mg/ mL) showed potential antiglycation ability. Cinnamon and Trigonella foenum significantly reduced advanced glycosylation end products (AGEs) and fructosamine formation, and also declined protein carbonyl contents and thiol group’s oxidation (P The findings illustrated that Cinnamon and Trigonella foenum extract improved hyperlipidemia and hyperglycemic. The hypolipidemic effect was likely by motivation of cholesterol 7-alpha hydroxylase activity. These plants also showed significant anti-diabetic effects in animal model by reducing blood glucose and inhibition of AGEs and fructosamine formation.