Effect of Fluoxetine on Ovarian and Oviduct Tissue in Female Mature Balb/C Mice

Use of antidepressants such as fluoxetine, which is widely used worldwide and easily accessible to the public, causes complications such as temporary or permanent infertility. The present study was conducted to investigate the effects of fluoxetine on the ovaries and oviducts of mature female Balb/C mice.
In this study after determining the appropriate dose of fluoxetine, it was injected intraperitoneally (IP) for 30 days into 75 adult Balb/C mice with doses of 15 mg/kg (group 1), 20 mg /kg (group 2), 25 mg /kg (group 3), control group (non-injection) and sham (distilled water injection). ANOVA analysis and Duncan test were used to compare the means with significant levels being considered (P During macroscopic examination, significant ovary weight decrease was observed in all three doses (P It can generally be concluded that fluoxetine has a damaging effect on ovarian and oviduct tissue of mice.