Sildenafil Citrate Can Reduce Pathological Post-obstructive Diuresis in a Rat Model of Bilateral Ureteral Obstruction

The current study aimed at assessing the effect of oral sildenafil citrate on postobstructive diuresis and urinary electrolyte changes after resolution of bilateral ureteral obstruction (BUO).
Twenty-eight adult Munich-Wistar male rats were subjected to the surgical-induced BUO for 24 hours. In intervention group (n = 14) sildenafil citrate 200 mg/kg food was administered from the operation day for 72 hours, while in control group (n = 14) no drug was used. Daily urinary volume, urine sodium (mEq/day), potassium (mEq/day), and osmolality (mOsm/kg H2O) were measured on the day before BUO and for 2 days after BUO release.
In comparison to the control group, postobstructive diuresis was significantly lower in the sildenafil group (P value Oral sildenafil citrate significantly decreased postobstructive diuresis and preserved urine sodium and osmolality near normal. These 2 effects mean a better preservation of renal function, while preventing pathological postobstructive diuresis.