Evaluation of the Plasma Level of Fibrinogen in the First Trimester in Mothers with Toxoplasmosis

Toxoplasmosis is a parasitic infectious disease. The occurrence of this disease brings about multiple complications resulting in abortion, death, or severe fetal complications. These complications may occur as a result of increased fibrinogen levels during pregnancy and increased serum factors associated with Toxoplasmosis. This study examined the plasma level of fibrinogen in the first trimester in mothers with acute toxoplasmosis for the first time.
In this study, 205 pregnant women who were referred to various medical centers of Tehran during 2014 - 2015 were studied. The bloods were examined for the levels of IgG avidity, anti - toxoplasma IgM and IgG, and fibrinogen levels. SPSS software v. 22.0 was used to study the results. Data regarding their demographic characteristics were collected by a questionnaire.
Among a total of 205 patients, 41 cases had positive IgG titer, two had positive IgM titer (one low avidity), and five were borderline. Fibrinogen level was high in one case of positive IgM titer as well as low avidity and positive in 10 out of 41 cases with IgG titers.
The results of the present study shows that increased levels of fibrinogen in pregnant women during the first trimester of pregnancy is not significantly associated with toxoplasmosis.