Synthesis and Characterization of Nanoporous Calcium Magnesium Silicate and Assessment of the Calcination Temperature Effect on Its Drug Delivery Behavior

In this study, the synthesis of nano-porous calcium magnesium silicate was performed and studied to improve drug properties and drug release. This synthesis was carried out by using the tetraethyl ortho silicate precursor (TEOS) and the Cetyltrimethyl ammonium bromide surfactant (CTAB) in a sol-gel alkaline environment; and the product was heat treated at 600° C and 800° C temperatures. The purpose of this study is to investigate the effect of the calcination temperature on the potential for ibuprofen release by the production produced compound. The product was studied using X-ray diffraction patterns (XRD), Nitrogen adsorption / desorption, Fourier-transform infrared spectroscopy (FTIR), ultraviolet spectroscopy (UV) and Transmission electron microscopy (TEM), and field emission scanning electron microscopy (FE-SEM). The results of Nitrogen absorption-desorption assay showed a surface area of 42-140 m2 /g The drug release after 240 hours showed that the calcite sample had a lower release at 600 ° C, temperature that which was is due to the smaller size of the cavities and the more surface area, as compared tothan the other specimens. Also, calcium and magnesium elements increased the loading capacity, and createcreating a suitable substrate for for the slower drug release. Overall, This this study showed that nano-porous magnesium silicate calcium has had the ability to load and release the ibuprofen and can could be, therefore, used as a modern drug delivery system in the bone tissue engineering field.