Voltammetric Determination of Venlafaxine by Using Multiwalled Carbon Nanotube- Ionic Liquid Composite Electrode

The combination of multi-walled carbon nanotubes and ionic liquid 1-octylpyridinium hexa flourophosphate (OPFP) yields a carbon nanocomposite (MWCNT-CILE) that can be well used as electrode for electrocatalytic oxidation of venlafaxine (VEN). The influence of various experimental parameters including pH of the solution, the amount of multi-walled carbon nanotube used for the modification of the carbon ionic liquid electrode (CILE), accumulation potential, accumulation time and scan rate on the voltammetric responses of venlafaxine were all investigated in the present research. The oxidation peak potential of venlafaxine appeared at 640 mV at the proposed electrode that is about 150 mV lower than the peak potential at traditional carbon paste electrodes (CPE). The oxidation is irreversible and exhibits adsorption controlled behavior. Under the optimum conditions, the anodic peak current has a linear relationship with venlafexine concentration in the range of 10.0 to 500.0μM. The detection limit (three times signal-to noise ratio) of 0.47μM was found. Finally, the proposed sensor has the features of being sensitive, reproducible, easily renewable and cost effective which might suggest promising applications for determination of VEN in pharmaceiutical formualations as well as blood serum and urine samples.