Pathological assessment of allograft nephrectomy: An Iranian experience
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
The aim of this study was to determine the pathologic causes of renal allograft failure in transplant nephrectomy specimens.Materials And Methods
In this cross?sectional study performed in the referral transplant center of Isfahan, Iran, medical files of all patients who underwent nephrectomy in 20082013 were studied. Age at transplantation, sex, donors characteristics, causes of primary renal failure, duration of allograft function, and pathologic reasons of nephrectomy were extracted. Slides of nephrectomy biopsies were evaluated. Data were analyzed using SPSS.Results
Medical files of 39 individuals (male: 56.4%; mean age: 35.1 ± 16.0 years) were evaluated. The main disease of patients was hypertension (17.9%), and most cases (64.1%) were nephrectomized 2 years posttransplantation. There were 14 cases in which biopsy results showed a relationship between primary disease of patients and pathologic assessment of allograft (P = 0.04). A significant relationship between transplantation?nephrectomy interval and both the nephrectomy result and histopathologic result existed (P Conclusion
The most pathologic diagnoses of nephrectomy in a period of less than and more than 6 months posttransplantation were RVT and TCMR, respectively. Early obtained allograft protocol biopsy is suggested, which leads to better diagnosis of allograft failure.Keywords:
Language:
English
Published:
Journal of Research in Medical Sciences, Volume:23 Issue: 6, Jun 2018
Page:
5
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