Low and High Frequency Band Connectivity in the Base Fluctuations of the Brain using fMRI Data of Parkinson Disease

Parkinson’s disease (PD) is a progressive neurological disorder characterized by tremor, rigidity, and slowness of movements. Different pathological attacks in Parkinson’s disease can be investigated by directional relations in the base spontaneous fluctuations of the brain from the resting state functional magnetic resonance imaging (RS-fMRI) data. In this paper, for analyzing the directional brain network at rest, Directed Transform Function (DTF) technique with graph theory has been used in two frequency sub-bands and intra/inter group connectivities were compared by statistical analysis. The result of group comparison between PD and healthy which has been done, showed that there are more significant connections in the low frequency band in Parkinson’s disease and control group compared to high frequency band. The relation between basal ganglia and cerebellum has been disturebed in Parkinson’s disease . Furthermore, some brain regions such as left cerebellum has the most information flow in healthy group which characterized by pivotal regions which were influenced by the other brain regions, this connection became disordered in Parkinsonism.