Effect of gallic acid on chronic restraint stress-induced anxiety and memory loss in male BALB/c mice
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Objective(s)
Long-term exposure to stress leads to memory deficits and certain mood disorders such as depression and anxiety. We aimed to study the effect of gallic acid (GA) on chronic restraint stress (CRS) induced anxiety and memory deficits in male BALB/c mice.
Materials and Methods
Ninety male BALB/c mice were assigned to nine groups including caged control (CC): food-water deprived (FWD), under chronic restraint stress (CRS), CRS+ gallic acid (5, 10, and 20 mg/kg), and gallic acid (5, 10, and 20 mg/kg). Behavioral assays were performed after 21 days of daily treatment with CRS and GA. Serum and brain levels of malondialdehyde (MDA) and total antioxidant capacity (TCA) and serum corticosterone level were also measured.
Results
Treatment of CRS mice with GA significantly improved passive avoidance memory in the shuttle box and ameliorated anxiety-like behaviors in the elevated plus maze (EPM) and open filed test (OFT). GA treatment significantly reduced elevated levels of serum and brain MDA and increased brain TCA. CRS and GA did not affect serum corticosterone levels. Treatment of healthy mice with GA had some adverse effects and induced some anxiety and oxidative stress.
Conclusion
GA exerted protective effects against stress-induced mood and memory deficit disordersKeywords:
Language:
English
Published:
Iranian Journal of Basic Medical Sciences, Volume:21 Issue: 12, Dec 2018
Pages:
1232 to 1237
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