The Effect of Clexane with Bondage and Bondage only in Prevention of Deep Vein Thrombosis in Patients Undergoing Instrumented Spinal Surgery

This study aimed to compare the effect of Clexane injection with bondage and bondage only in the prevention of deep vein thrombosis in patients undergoing instrumented spinal surgery. In a clinical trial study, 300 patients under instrumented spinal surgery were selected and randomly divided into two equal groups. In the first group, bondage was used with injection of 1 mg/kg Clexane daily until patient’s ambulatory, and in the second group, bondage was used only. All patients were followed up for 14 days, and the incidence of deep vein thrombosis was determined and compared between the two groups. Findings: 4 patients suffered from deep vein thrombosis, 3 of them (2.0%) were in the control group and 1 (0.7%) in the treatment group (bondage and Clexane); but the incidence of deep vein thrombosis was not significantly different between the two groups (P = 0.620). The mean volume of bleeding was significantly higher in patients receiving Clexane (203.4 ± 8.3 ml) than control groups (163.0 ± 7.7 ml) (P < 0.001). There was no significant difference between the two groups of bondage alone and bondage and Clexane in preventing deep vein thrombosis. On the other hand, there is still no study to prove the definitive effect of this drug in preventing deep vein thrombosis and thromboembolism. Therefore, more studies are recommended to be done with larger sample sizes in order to determine the effect of Clexane in preventing deep vein thrombosis