Antibacterial and Antioxidant Potential of Haliclona caerulea Extracts from Tidal Island Larak, Persian Gulf

Considering the importance of health and some disadvantages of the existing synthetic compounds, the present research aimed at evaluating the antibacterial and antioxidant potential of Haliclona caerulea extracts. In the present experimental study, organic extracts of n-hexane, diethyl ether, and methanol were prepared by the Bligh and Dyer method from the marine sponge; then, antibacterial activity was measured by disc diffusion, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC), and antioxidant activity was measured by evaluating the regenerative power and determining the total antioxidant capacity of the extracts. The data were analyzed by Duncan's new multiple range test (MRT) one-way ANOVA test. SPSS 19 and Excel 2013 software were used. Findings: Methanol extract had the most antibacterial effect, especially against Gram positive bacterial of Bacillus subtilis with a concentration of 2.5mg/ml and Staphylococcus aureus with a concentration of 5mg/ml. Diethyl ether extracts showed the highest antioxidant activity at concentration of 5mg/ml. The methanol extract of Haliclona caerulea exhibits more antibacterial properties, and the diethyl ether extract of this sponge have a higher antioxidant effect.