Design of Alternating Magnetic Field Generator for Magnetic Fluid Hyperthermia Research Application

Hyperthermia utilizing nanoparticles is a novel cancer therapy which relies on the heat released when nanoparticles inside a tumor are exposed to an alternating magnetic field. The field strength and frequency are the main variants affect performance of nanoparticles for heat generation. Besides the characteristics of nanoparticle, which is the main criteria for tuning amplitude and frequency of magnetic field generated by an alternating magnetic field generator (AMFG), several parameters should be considered for an optimum design, which is related to AMFG design. These parameters are input voltage range, copper tube resistance used for solenoid coil, coil number of turns, and etc. According to these criteria, design procedure of AMFG for research applications is performed to maximize the heat released by nanoparticles. In order to validate the design, an experimental set up of AMFG is prepared which is used for in vivo hyperthermia tests. The experimental results are shown and compared to the simulations.