The Preemptive Effect of Pregabalin Single Dose on Opioid Consumption after surgery of Mandible Fracture: The Double-Blinded Clinical Trial

Currently, the administration of non-opioid analgesics as a preemptive treatment has been approved by the surgeons of jaw due to lack of side effects of opioids in jaw surgery. However, which medicine as a pre-medication has a good result, is a controversy. Therefore, the aim of this study was to investigate the effect of preemptive therapy by pre-gabalin single dose on opioid consumption rate after surgery on mandibular fractures. This double-blind clinical trial was conducted in Tabriz Imam Hospital in 2012 on 60 patients who were undergoing mandibular fracture surgery. Patients were classified as intervention and control groups and the intervention group consumed one pregabalin capsule 300 milligrams with 50 ml of water half an hour before surgery. The amount of opioid use in the first eight hours after surgery was measured and recorded in both groups. Opioid use in both groups was decreased with time- spending. There was also a significant relationship between opioid use in both intervention and control groups (P <0.001). Pregabalin premedication could have analgesic effects in lower jaw fracture surgery and decrease opioid use after surgery.