Effect of eight weeks continues and HIIT exercises on VEGF-A and VEGFR-2 levels in stratum, hippocampus and cortex of wistar rat brain

The purpose of this study was to investigate the effect of eight week continues and HIIT exercise on VEGF-A and VEGFR-2 levels in stratum, hippocampus and cortex of wistar rat brain. for this purpose, 24wistar rats (age: 9 weeks, weight: 200±20gr) were selected. After one week of familiarization with laboratory environment, they were randomly divided into three groups consisted of: control, continuous training and high intensity interval training. They did continuous and high-intensity interval training for eight-weeks. Twentyfour hours after last section of exercise they sacrificed and sampling of stratum, hippocampus and cortex were performed. Then, for assessment of VEGF-A and VEGFR-2 level, western blot method was used and for statistical analysis of the data's, the one-way ANOVA was used. Data of this study illustrated that VEGF-A protein in the stratum in HIIT and in hippocampus, the continuous training and in the cortex HIIT group was
higher than the control group (P< 0/..5). Also VEGFR2 protein in the stratum and hippocampus area in both groups were higher than control group. While this difference was not significant in cortex. The results showed that both continuous and high-intensity interval training can increase the amount of VEGF-A and VEGFR2 proteins. Thus HIIT because of the time advantage can