Effect of 8 week endurance training on plasma and heart tissue collagen XVIII in male Wistar rats

the aim of this study was to examine the effect of endurance training on plasma and heart tissue collagen XVII in male Wistar rats.

16 male Wistar rats (4-6 week old, 125-135 g weight) were randomly divided two groups: experimental (n=8) and control (n=8) groups. Training protocol consisted of treadmill exercise at 20 to 60 min, speed 28 to 34 m/min, (0%) grade, for 5days/week for 8 weeks. Rats were sacrificed 72 h after the last session of exercise for measurement collagen XVIII levels in plasma and heart tissue. Plasma and tissue collagen XVIII levels measured using ELISA. Data were analyzed using independent t-test at P= 0.05. Results collagen XVIII levels increased in plasma and heart tissue after 8 weeks endurance training, but significant difference observed only in heart tissue (P=0.046).

It likely appears that increased of collagen XVIII was indicatorm of exercise training effect on anti-angiogenesis and confirmed the anti-cancer impact of exercise training.