Prevalence of autoimmune thyroid disease in recurrent aphthous stomatitis
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Introduction
Recurrent aphthous stomatitis (RAS) is a multifactorial recurrent oral lesion; which is an autoimmune disease. TH1 cytokines are the most important etiological factors. Autoimmune thyroid disease (ATD) is one of the most common autoimmune diseases and generally coexists with other autoimmune diseases. This study assessed the prevalence of thyroid disease in
patients with recurrent aphthous stomatitis.
Materials and Methods
This case control study assessed 100 patients with RAS. Oral medicine specialists diagnosed RAS clinically; venous blood samples were analyzed for thyroid stimulating hormone (TSH), free triiodothyronine (fT3), total thyroxine (fT4), thyroglobulin, anti- thyroid peroxidase antibody (anti-TPO) and anti-thyroglobulin antibody (anti-TG) levels.
Results
Fifty patients with RAS aged between 18-42 years (28.5±5.8) and 50 healthy volunteers aged 19-45 years (27.3±5.4) participated. In RAS patients, fT3 and TSH levels were significantly higher (P=0.031, P=0.706); however, fT4 level was lower in the RAS group (P=0.447). Anti TG and anti-TPO levels were significantly higher in the RAS group (P=0.008, P=0.067).
Conclusion
Our study showed that ATD prevalence was significantly higher in RAS patients. Based on this study, we recommend assessment of thyroid hormones and antibodies in RAS patients. Keywords: Recurrent aphthous stomatitis; Thyroid autoimmune disease; Thyroid hormone, Thyroid antibodies.
Keywords:
Language:
English
Published:
Journal of Craniomaxillofacial Research, Volume:5 Issue: 4, Autumn 2018
Pages:
164 to 168
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