Fabrication of Alginate-Gelatin Hydrogel with Quercus Brantii Galls (Oak) and Silver-Nanoparticles as a Burn Wound Dressing

Burns are one of the most important accidents related to human health. Receiving proper treatment is very important due to the intense complications associated with them. The improvement and elimination of ulcer effect can be achieved by controlling the wound infection. According to this, wound dressing containing antibiotics is one of the effective methods in wound's infection treatment. The use of silver in burns caring has been considered a long time ago, but silver deposits on the liver that causes some problems which can be overcome with the help of nanotechnology. In this study, Silver-Oak nanoparticles were green synthesized by using the ethanol extraction of Iranian Oak with the help of reducing agent. Nanoparticles formation were followed by UV-Visible spectrum and they characterize with SEM images and XRD spectrum. Then Gelatin-Alginate Hydrogel was prepared as a wound dressing and their properties were investigated by the presence of nanoparticles, oak extraction and without any additives. Nanoparticles' diameter is about 30-65nm which are dispersed in the hydrogel with regular pore size about 30-100μm. Oak extraction increase the hydrogel water uptake that improve the wound hilling. Antibacterial properties of wound dressing against Staphylococcus aurous and pseudomonas are investigated by inhibiting zone.