The main aim of the present study was to design, fabrication and physicochemicalcharacteristics of the magnetogel nanospheres as carriers for Cisplatin in the in vitro environment.

Magnetic nanospheres were synthesized by using a chemical co-precipitation methodand coated by sodium alginate through double emulsion method. Then cisplatin was encapsulatedinto β-cyclodextrin -sodium alginate grafted magnetic nanospheres. The physicochemicalproperties of the sodium alginate grafted magnetic nanospheres were characterized by using FTIR,particle size analyzing, vibrating sample magnetometry, thermogravimetric and SEM analysis.Also the drug entrapment efficiency, content and in vitro release profile were investigated.

Size distribution results revealed that the particles size was distributed in the rangeof 50± nm. Also morphological properties showed that particles are separated and sphericalwith the grafted layers of the polymer. The release profile data were in the acceptable rangecompared to the blank (cisplatin solution).

It could be concluded that the sodium alginate grafted magnetic nanospheres couldact as a slow and controlled release system to deliver cisplatin.