Maternal Hepatitis B Virus Infection, Pregnancy, and Infant Health Outcomes in Botswana
Message:
Abstract:
Background

Hepatitis B virus (HBV) infection during pregnancy is associated with an increased risk of premature birth, cesarean sections, low birth weight, and an increased number of hospitalizations in infants. There are no reported data on the impact of maternal HBV status on pregnancy and infant health outcomes in Botswana.

Objectives

We aimed to evaluate the association of maternal HBsAg+/occult HBV infection at delivery with pregnancy and infant health outcomes in Botswana.

Methods

HBsAg positivity was tested using a murex HBsAg ELISA kit while occult HBV (OBI) was tested using COBAS® AmpliPrep COBAS® Taqman®.

Results

The total number of maternal HBsAg+ and OBI infections was 57 out of 752 and termed as maternal HBV. Binary logistic regression was used to explore the possible impact of maternal HBV status on each outcome, adjusted for maternal HIV status, ART use during pregnancy, and maternal age.

Conclusions

In conclusion, there was no association between maternal HBsAg+/occult HBV infection and preterm birth (< 37 weeks), stillbirth, low birth weight (< 2.5 kg), and infant hospitalization (by 24 months).

Article Type:
Brief Report
Language:
English
Published:
Hepatitis Monthly, Volume:19 Issue:10, 2019
Page:
4
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