Electrochemical Investigation of Uric Acid using MWCNTs-Decorated Novel Substituted Cobalt(II) Phthalocyanine Modified GCE

The present work is very simple and sensitive method for cyclic voltammetry, differential pulse voltammetry and chrono amperometry (CA). Uric acid sensor was developed at (DBCMAT-CoPcs) 2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline-tetra substituted on cobalt phthalocyanine modified GCE. The novel synthesized catalyst confirmed with various spectroscopic techniques. The modified DBCMAT-CoPc/GCE showed a high electrocatalytic activity and lower potential towards the oxidation of uric acid (UA). The response of UA was linear over the concentration ranging from (CV 0.1–1.8; DPV 0.2–2.8; CA 0.05–0.8 μmol/L), sensitivity for (CV 131.85; DPV 22.634; CA 2.509 μAμM-1cm-2) and detection limit for (CV 0.03; DPV 0.066; CA 0.016 μM) (S/N=3). The CVs and DPV techniques shows the same peak potential (+370 mV) and fabricated sensor exhibited its special advantages such as low working potential, sensitivity along with good repeatability and reproducibility for the determination of uric acid.