Intratumoral Heterogeneity in Breast Cancer: A Case Report and Molecular Discussion

The emerging era of personalized medicine makes it increasingly important toc onsider intratumoral heterogeneity, which has been found in some breast cancerc ases. However, its identification criteria, form of reporting, and subsequent effects ont he clinical course of this disease remain controversial and not fully defined. Here, wer eport and discuss a case of breast invasive ductal adenocarcinoma with substantiali ntratumoral heterogeneity, discrepancy between Her2/neu immunostaining and ins ituhybridization, and disparity between estrogen receptor status before and aftern eoadjuvant therapy.