Pelargonidin improves amyloid β-induced deficits in the long-term potentiation in hippocampus of male rats

Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Introduction

Given that pelargonidin is an anthocyanin that exhibits neuroprotective effects and Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-beta (Aβ) and cognitive dysfunction subsequently, herein, we examined the effects of pelargonidin on Aβ-induced long-term potentiation deficits in rats.

Methods

AD was induced using intrahippocampal injections of the Aβ in the adult Wistar male rats. The rats received single intraperitoneal injections of pelargonidin (3mg/kg). Long-term potentiation in the perforant path- dentate gyrus synapses was assessed electrophysiologically by measuring the field excitatory post-synaptic potential (fEPSP) slope and population spike (PS) amplitude.

Results

Our results showed that Aβ significantly decreased fEPSP slope and SP amplitude in comparison with the control and sham groups, whereas pelargonidin increased these parameters in comparison to the Aβ group.

Conclusion

It is probably that pelargonidin could improve Aβ-induced cognition deficit in rats.

Language:
English
Published:
Physiology and Pharmacology, Volume:23 Issue: 4, Dec 2019
Pages:
296 to 301
magiran.com/p2075537  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 1,390,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!