Simulation of Different folliculogenesis pathways in cattle using Systems Biology Markup Language (SBML)

Folliculogenesis is the maturation of the ovarian follicle, a densely packed shell of somatic cells that contains an immature oocyte. On the other hand, TEK signaling plays a very important role in folliculogenesis. It activates Ras/ERK/MYC, PI3K/AKT/mTORC1 and ovarian steroidogenesis activation pathways. These are the main pathways for cell growth, differentiation, migration, adhesion, proliferation, survival and protein synthesis. So, we have developed mathematical models relate to the different TEK signaling in dominant (> 10 mm) and subordinate follicles (< 5 mm) using systems biology markup language in Matlab environment. Simulation denotes the effect of different expression levels of ANGPT1, TEK, MYC, MAPK1, PIK3R1, MCL1 and EIF4EBP1 and increased expression of certain factors in folliculogenesis TEK signaling on each of the two important pathways where levels of pERK, pMYC, pAkt , pMCL1 and pEIF4EBP1 are increased in dominant follicles and pMYC is decreased in dominant follicles. Over activation of ERK and MYC which are the main cell growth and proliferation and over activation of Akt, MCl1, mTORC1 and EIF4EBP1 which are the main cell survival and protein synthesis factors act as promoting factors for folliculogenesis. Finally, the simulation of signaling pathways may give new insights into biological procedures.