Evaluation of Platelet Rich Fibrin in the Management of Gingival Recession Type I/II by Miller: A Randomized Clinical Split Mouth Study

The ultimate goal of mucogingival plastic surgery is to obtain complete root coverage and an optimal appearance. The aim of this study was to evaluate the efficacy of platelet-rich fibrin (PRF) with coronally advanced flap (CAF) compared to connective tissue graft (CTG) with CAF in the treatment of gingival recession (GR).

A total of 20 patients were included in this randomized clinical study, presenting 40 GR Miller type I/II. The GR sides of patients were assigned randomly into test group (PRF + CAF) and control group (CTG + CAF). Clinical parameters, such as GR, probing depth (PD), clinical attachment level (CAL), and width of keratinized gingiva (WKG), were evaluated at baseline and 12 months later. Root coverage (RC %) and complete root coverage (CRC %) were assessed at 12 months post surgically. Statistical analysis was performed using paired, independent t-test and Mann–Whitney U test. Statistical significance was set at 0.05.

At 12 months the mean (SD) GR was 0.20 ± 0.50 mm for test group and 0.05 ± 0.15 mm for control group, whereas the mean RC% was 95.32 ± 11.92 for PRF + CAF and 98.61 ± 4.37 for CTG + CAF. CRC was obtained in CTG + CAF with 90% and with 80% in PRF + CAF. CAL gain was 2.80 ± 0.28 mm and 2.49 ± 0.55 mm in test and control sites, respectively. The gain of WKG was 1.31 ± 0.45 mm and 1.85 ± 0.25 mm in test and control sites, respectively. All the values were not significantly different (P ≥ 0.05).

Using of PRF + CAF in the treatment of GR is a successful and effective treatment option and could serve as an alternative to CTGs.