Long Non-coding Ribonucleic Acid as a Novel Diagnosis and Prognosis Biomarker of Bladder Cancer
Long non-coding ribonucleic acids (lncRNAs) are the largest group of non-coding RNAs,supposedlyhave a broad spectrum of diverse functions in normal cellular processes. This study was carried outto review the biological functions of candidate lncRNAs (i.e.,H19,MALAT-1,TUG1,UCA-1,MEG3,HOTAIR,CCAT2,AATBC,and the like) with aberrant expressions that play critical roles in bladdercancer (BC) initiation,progression,and metastasis. A formal narrative review was performed by searchingthe PubMed database for English articles using a combination of keywords such as “long non-codingRNA”,“lncRNA”,“cancer”,“bladder cancer”,“screening”,“prognosis”,“diagnosis”,and “response totherapy”. In addition,the existing literature was studied on biological function,aberrant expression,and the clinical applications of candidate lncRNAs in BC. By a better understanding of the molecularmechanisms of lncRNAs,they can be used as biomarkers for tumor signatures in urologic malignancies,which can improve screening,prognosis,diagnosis,and the treatment of BC.
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.