Response of Serum Levels of Adiponectin and Insulin Resistance Index in Obese Male Rats to Two Types of Aerobic Exercise

 Adiponectin is mainly produced by adipose tissue and there is an inverse relationship between circulating adiponectin levels and metabolic syndrome, obesity, and cardiovascular disease. The aim of this study was to investigate the effects of eight weeks aerobic training with moderate and high intensities on serum levels of adiponectin and insulin resistance index in obese male rats.

In this experimental study, 24 adult obese male Wistar rats (weight: 250 to 300 gr, BMI >30g/cm2) divided into three groups: aerobic training with 28 m/min (MI=moderate intensity), aerobic training with 34 m/min (HI=high intensity) and, (C=control) group. All training groups carried out exercise training for 8 weeks (5 sessions per-week for 60 min per session). Data were analysis with one way ANOVA to determine the intra and difference between groups and for post hoc test was Tukey test.

The levels of adiponectin in MI group (p=0.04) and HI (p=0.04) rather than C group increased. Moreover, there is no differences between eight weeks aerobic training with MI and HI groups on adiponectin levels (p=1.00). The levels of FBS and insulin in MI and HI groups rather than C group reduced; in the other hand this change were not significant (p>0.05). The levels of insulin resistance index in MI group (p=0.01) and HI (p=0.01) rather than C group reduced significantly.

It seems that both of the aerobic training has a better effected on prevention of obesity and cardiovascular disease.