Application of polypyrrole-cerium (IV) oxide nanocomposite as a nanosensor for measuring Levocarnitine drug

Among different conductive polymers, polypyrrole has been more concerned with biocompatibility, simple polymerization and chemical stability. In this research, the electrochemical synthesis of polypyrrole-cerium (IV) oxide nanocomposite has been done by cyclic voltammetry method on graphite electrode and used as a sensor. Synthesis of Cerium (IV) oxide (CeO2) nanoparticles was done by chemical sedimentation method. X-ray diffraction (XRD), transmitted electron microscopy (TEM), and scanning electron microscopy (SEM) images confirm the nanoscale synthesis of in the 10-40 nanometer range. Synthetic nanocomposite is used for the sensor of Levocarnitine, one of the derivatives of amino acids, used to oxidize fatty acids and generate energy in the body. The results of the investigation of the nano-sensor behavior confirm the detection limit of 6 × 10-9 M and the measurement limit of 2 ×10-8 M. The percentage of recovery in the real sample was also 101%, which indicates the sensitivity of this method to the measurement of Levocarnitine.