Synthesis of Crown Ethers from Indole Using Nano TIO2 as an Efficient and Recyclable Catalyst

In this research, due to the high importance of crown ethers in complexometric and also in the field of pharmacology, a new method for the preparation of several heterocyclic crowns ethers was proposed using titanium nano-oxide catalysts. To this end, the reaction of 2-methyl-indole with tosylated triethylene glycol, led to the formation of 2-methyl-1- (2- (2- (2- (2-methyl-H1-1 -indole (ethoxy) (ethoxy) ethyl) -1H-indole in DMF solvent and the KOH. After determining the optimum conditions for the preparation of the crowns (room temperature, dichloromethane solvent and the catalytic ratio of 5 mol%), the chronological derivatives of the crown ethers were obtained from the reaction of the 2-methyl-1- (2- (2- (2- (2-methyl-H1-1 -indole (ethoxy) (ethoxy) ethyl) -1H-indole with different derivatives of aldehydes. One of the advantages of this method is the high efficiency, non-toxicity of the catalyst, and its reuse.