Effective materials of medicinal plants for leishmania treatment in vivo environment

Treatment of leishmaniasis is a challenge due to problems such as high price and dose of the drug, drug resistance and side effects.

The study aims to introduce plants compounds, which their antileishmanial effects were approved in vivo conditions.

This study as a review article was performed by searching the keywords of “medicinal plants with in vivo antileishmanial effects, nanocarrier, clinical trials, and mechanism of action” in the well-known databases to 2018. In this study, 14 medicinal plant compounds with antileishmanial effects were reviewed and mechanism of action and their in vivo therapeutic effect were evaluated.

It was found that while some of these compounds had low antileishmanial effects, their efficacy against leishmaniasis was significantly increased through loading into nanocarriers.

This study indicated that active component of medicinal plants especially along with nano carriers can be of interest for the treatment of Leishmania.