The Effect of Vitamin D Supplement on Outcomes in Patients with Traumatic Injuries Hospitalized in Intensive Care Unit: A Clinical Trial Study

As published in literature, vitamin D deficiency lead to increased morbidity and mortality rate in patients who hospitalized in intensive care units (ICUs). The present study conducted to evaluate the effect of vitamin D supplement on outcomes in patients with traumatic injuries hospitalized in ICU.

 In a clinical trial study, 55 patients with low levels of vitamin D (less than 30 ng/ml) and 55 patients with normal levels of vitamin D were selected from the patients admitted to the ICU of Alzahra hospital, Isfahan, Iran. The patients suffering hypovitaminosis D (interventional group) received 300,000 units of vitamin D intramuscularly. Patients who had adequate vitamin D levels were considered as control group. The patients’ recovery from the ICU was evaluated and compared by the Sequential Organ Failure Assessment (SOFA) index.

 SOFA scores were significantly higher in vitamin D deficiency group in first 2 weeks after hospitalization. Serum vitamin D levels at the end of the 3rd</sup> week had no statistical different between the two groups. The discharge rate in vitamin D deficiency group in first 2 weeks were lower than control group significantly. But at the end of the third week, the difference between the two groups was not significant.</div>

The results of our study showed that vitamin D supplement increased discharge rate of traumatic patients hospitalized in ICU.