Frequency of Sperm DNA Fragmentation Index in Infertile Couples With Male Factor Infertility

Today, sperm DNA fragmentation is considered as one of the causes of male infertility. The aim of this study was to investigate the frequency of sperm DNA fragmentation index (DFI) in male factor infertility.

This cross-sectional study was performed on 100 infertile men referred to Infertility Clinic of Zahedan (Iran) in 2017. Patients were selected using simple random sampling. All sperm parameters were analyzed for the patients. The sperm DFI was determined using Halosperm test and patients were divided into two groups with low sperm DFI (≤30%) and high sperm DFI (>30%).

The mean age and sperm DFI of patients were 34.29 ± 4.18 years and %34.69 ± 19.13, respectively. From these patients, 55% had low DFI (less than 30%) and 45% had a high DFI (greater than 30%). The normal sperm morphology in the group with sperm DFI greater than 30% significantly was lower than that in the group with sperm DFI less than or equal to 30%.

The findings of this study indicated an inverse relationship between sperm DFI and sperm morphology. Conducting DFI tests to examine the anomalies and sperm DNA damage in infertile men is highly recommended.