The effect of ginger (Zingiber officinale) feed on cardiac biomarker in medium-dose isoproterenol-induced myocardial toxicity

Objectives:

 Traditional medicines have been widely used to prevent and treat diseases for thousands of years. This study was designed to evaluate the effect of ginger feed on cardiac biomarker in isoproterenol induced myocardial toxicity.

Materials and Methods:

Thirty male wistar rats were grouped into six groups of 5 rats each: Control; ISO- induced toxicity; ginger fed ; ginger fed before; ginger fed+ isoproterenol simultaneously and ginger fed after. Freshly prepared solution of isoproterenol was injected subcutaneously at a dosage of 20mg/kg, while the control recieved distilled water. Blood was collected via cardiac puncture after two weeks of administration, the serum was used to evaluate biomarkers.

Results:

The CK-MB of ginger fed groups was significantly lower (p < 0.05) compared to ISO group(8.2 ± 0.5µ/L). The CK of the ginger fed groups showed significant decrease (p>0.05) compared to isoproterenol group (39.36±5.28 µ/L), there was no significant difference in the CK-MB and CK levels of all the groups fed with ginger compared to the control(2.2± 0.3µ/L; 17. 07 ± 3.4.90 µ/L) except the group that was fed with ginger after isoproterenol induction, which was significantly higher compared to the control(p>0.05). The mean value of LDH were lower in all ginger treated groups compared to the ISO group (67.17± 0.88; p≤ 0.05), but significantly higher (p < 0.05) compared to the control(26.45 ± 2.52). The mean value of ALT were lower in all ginger fed groups compared to the ISO group (83.11± 4.88; p ≤ 0.05).

Conclusion:

Ginger feed hindered toxic effects of isoproterenol.