The Effects of Endurance Training with Stanozolol Treatment on hepatic enzymes of male rats

The purpose of this study was to investigate the effects of six weeks endurance training and treatment of stanozolol on hepatic enzymes (ALT, AST and ALP) in male healthy rats. For this reason, 32 male Wistar rats aged 12 weeks old (initial body weight, 289±16g) were divided randomly into four groups; placebo (P, n=8), exercise (E, n=8), exercise stanozolol (ES, n=8) and stanozolol (S, n=8). ES and S groups received a weekly intramuscular injection (5mg/kg of body weight) of stanozolol, while P and E groups received Arashiz oil as placebo. E and ES groups were submitted to a progressive running program on a treadmill, for 6 weeks and 5 days per week. ALT, AST and ALP serum levels were measured by ELISA method. Data were analysed by one way ANOVA test, (p < 0.05). ALT (P=0.002) and AST (P=0.001) changes were significant but ALP changes were not significant. According to the findings of this study, endurance training could not modulate possible side effects of stanozolol on liver tissue.