Association of Transforming Growth Factor-β1 rs1982073 Polymorphism with Susceptibility to Acute Renal Rejection: a Systematic Review and Meta-Analysis

The association of rs1982073 (codon 10) polymorphism at Transforming Growth Factor- β1 (TGF-β1) gene with acute renal rejection (ARR) has been reported by several studies. However, the results were controver-sial. To derive a more precise estimation of this association, a meta-analysis was performed.

The eligible literatures were identified through PubMed, Scopus, Web of Science, EMBASE, SciELO, WanFang, and CNKI databases up to July 01, 2019. The pooled odds ratios (ORs) with corresponding 95% confi-dence intervals (CIs) were used to calculate the strength of the association.

A total of 23 case-control studies with 795 ARR cases and 1,562 non-AR controls were selected. Pooled data revealed that there was no significant association between TGF-β1 codon 10 polymorphism and an increased risk of ARR in the overall population (C vs. T: OR=0.908, 95% CI 0.750-1.099, p = 0.322; CT vs. TT: OR=1.074, 95% CI 0.869-1.328, p = 0.507; CC vs.TT: OR=0.509, 95% CI=0.738-1.253, p = 0.770; CC+CT vs. TT: OR = 0.917, 95% CI 0.756-1.112, p = 0.376, and CC vs. CT+TT: OR=0.995, 95% CI 0.809-1.223, p = 0.959). Moreover, stratified analysis revealed no significant association between the TGF-β1 rs1982073 polymorphism and ARR risk by ethnicity and cases type (recipient and donor).

The current meta-analysis demonstrated that the TGF-β1 rs1982073 polymorphism was not signifi-cantly associated with increased risk of ARR. However, studies with a larger number of subjects among different ethnic groups are needed to further validate the results.