Design and Scale-up of Mixed Bioreactors Using Computer Simulation

One of the problems in the biotechnology industry is the discrepancy between the experimental results and the pilot results. Therefore, in this research, the scale-up of bioreactors as one of the main issues in the industrialization of laboratory research is discussed. In this research, scale-up calculations based on Reynolds number and momentum factors, blade speed (NDi and N), and constant mass transfer mass coefficient (KLa) are investigated. Since simulations of these criteria are manually time-consuming, computer simulation is essential. Therefore, in the present study, the scale-up of mixed bioreactors was simulated by excel software. Results of this research for scale-up of a bioreactor from 100 liters to 125 liters and from 80 liters to 10000 with other researchers were compared and confirmed. However, using this software, you can make the optimization on a larger scale in the shortest possible time, which reduces costs such as optimization costs, labor costs, and more. Also, the use of this software can help engineers to make predictions on larger-scale production.