The Evaluation of the Effect of Hypothyroidism Treatmenton Non-Alcoholic Fatty Liver Disease

There is still controversy over the existence of a relation between hypothyroidism and fatty liverdisease. The scale by which hypothyroidism can affect fatty liver disease progression is also to be determined.Therefore, our study aims to contribute in the determination of this relation.

This ob-servational analytical-before and after study with 53 patients was conducted. The subjects were categorized ashaving either primary or subclinical hypothyroidism. The serum levels of thyroid stimulation hormone (TSH),free T3 (FT3), free T4 (FT4), alanine transaminase (ALT), aspartate aminotransferase (AST) and alkaline phos-phatase (ALP) were measured and liver ultrasound was done to screen nonalcoholic fatty liver disease (NAFLD).

The study consisted of 41 women and 12 men with the mean age of 48.3 years. The mean TSH levelsdecreased after hypothyroidism treatment in patients. The mean levels of FT4 did not have a significant increaseafter treatment, although in patients with subclinical hypothyroidism this increase was significant. T3 levels in-creased significantly after treatment. Statistical studies showed that there was a significant change in the degreeof fatty liver before and after hypothyroidism treatment.

There was an explicit relation betweenhypothyroidism and non-alcoholic fatty liver disease as Hypothyroidism treatment can prevent non-alcoholicfatty liver disease progression.