Electrochemical Amplified Sensor with Mgo Nanoparticle and Ionic Liquid: A Powerful Strategy for Methyldopa Analysis

In this research, an amplified sensor based on paste electrode (PE) modified with MgO nanoparticle (MgO/NPs) and 1-hexyl-3-methylimidazolium hexafluorophosphate (HMH) was designed and used for determination of methyldopa (MD). The CP/MgO/NPs/HMH showed good catalytic activity toward oxidation of MD and improved drug current about 3.58 times. In addition, CP/MgO/NPs/HMH showed a diffusion process and pH dependence behavior for electro-oxidation of MD in aqueous solution. However, differential pulse voltammogram of CP/MgO/NPs/HMH showed a linear dynamic range to sensing of MD in concentration range 1.0 nM – 400 µM with detection limit 0.5 nM. The recovery range 98.25% - 102.5% was obtained for sensing of MD in real samples using CP/MgO/NPs/HMH.