The Effect of Aerobic and Resistance Training on Some Coagulation (PAI-1, Fibrinogen, PT, PTT) and Fibrinolysis (t-PA, Plasminogen and D-Dimer) Factors in Sedentary Obese Women

Obesity contributes to disrupt balance between coagulation (increasing) and fibrinolysis (decreasing) factors and is effective in inducing thrombosis. Physical activities play a role in controlling the damages caused by obesity. Therefore, the aim of this study was to investigate the effect of 8 weeks of aerobic and resistance training on PAI-1, fibrinogen, PT, PTT, t-PA, plasminogen and D-dimer. 30 sedentary women (age: 25-30 years, body mass index: 30 Kg/m2) voluntarily participated in this study and were randomly divided into three groups: aerobic training, resistance training and control. Aerobic training was performed 3 sessions a week, 30-45 minutes each session with an intensity of 60-85% of maximum heart rate. Resistance training was performed based on 10RM, following the principle of overload for 8 weeks. Data were analyzed by ANOVA and dependent t test (P<0.5). Aerobic training significantly increased tPA compared to control and resistance training groups (P=0.001). Both resistance and aerobic training significantly increased prothrombin time (PT), PAI-1, plasminogen and D-dimer (P=0.001) compared to the control group. Aerobic training significantly increased (P=0.001) and resistance training significantly decreased (P=0.003) fibrinogen compared to the control group. The partial thromboplastin time (PTT) increased in the resistance training group (P=0.03) and decreased in aerobic training group (P=0.001) compared to the control group. Aerobic training has a better effect on important fibrinolysis factors including t-PA, while resistance training has a better control on some important coagulation variables including fibrinogen