Synthesis of High Biocompatible Mesoporous Silica Nanocarriers with Regular and Uniform Pore Distribution for Doxorubicin Drug Delivery

In this study, biocompatible mesoporous silica nanocarriers were synthesized with the regular and uniform pore distribution from natural sources of rice and wheat husk under sol-gel process for sustainable drug delivery to breast cancer cells. The physicochemical properties of nanocarriers were investigated by XRD, FT-IR, SEM and BET analyzes. Nanocarriers obtained from rice and wheat husk had a specific surface area of 741.44 and 630.52 m2/g, respectively, with regular and uniform pore distribution with a size of 2.58 and 3.63 nm. Doxorubicin was loaded as a model drug into the nanocarriers and drug release was evaluated at pH 7.4 and 5.4. The results showed that the drug release rate doubled under acidic conditions which simulating the tumor environment. By examining the cytotoxicity of nanocarriers on the HFF-2 and MCF-7 cell lines, it was found that the nanocarriers have high biocompatibility and prevent the growth and cause to cancerous cells death.