Synthesis, characterization of magnetic nanoparticles of functionalized magnetite by sulfamic acid and catalytic application for the synthesis of propargylamines under solvent-free conditions

Propargylamines derivatives have been reported to possess a wide range of pharmaceutical activities or can be converted to some compounds with similar properties In this project, sulfamic acid stabilized on silica coated Fe3O4 magnetic nano particles was prepareded and characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA). Then this catalyst used as a magnetically retrievable catalyst in the synthesis of different propargylamines by the reaction of various aldehydes, secondary amines and terminal alkynes at 80 °C under solvent-free conditions in high yields. This method is not only high yields and low cost due to solvent free conditions, but also due to having magnetic core catalyst can be easily separated using an external magnetic field and reused up to five times. It is worth noting that the difference in yields between the first and fifth catalyst recycling was less than 12%.