Variations of Plasma Adrenomedullin, Ventricular Ejection Fraction and Resting Rate Pressure Product, Following Rehabilitation Programs of Interval and Continuous Training after Coronary Artery Bypass Grafting Surgery

Background and Aims :

Adrenomedullin (ADM) is one of the important cardiovascular indices and affects the function of the circulatory system. The purpose of this study was to determine the effect of rehabilitation programs of interval and continuous training on plasmatic ADM, ventricular ejection fraction (EF), and resting rate pressure product (RPP) after coronary artery bypass grafting surgery (CABG).

Methods:

 36 POST-CABG patients (27 men and 9 women) were selected purposive and then divided into three groups randomly: control group (C), aerobic continuous training (ACT), and aerobic interval training (AIT) (exercise training program was performed 3 days/week for 8 weeks) with intensities %65 to 80% and 80% to 95% of reserve heart rate in order. Blood sampling and 2D echocardiography were performed for measuring plasmatic ADM (Elisa technic) and ejection fraction (EF). Resting RPP was also measured by a digital blood pressure system. Paired sample t-test and ANOVA tests analysis were used for data analyzing

ADM and resting RPP were decreased and EF was increased in both training groups, But these changes were significant only in the AIT group (P≤0.05) and there were significant differences between the AIT and other groups in EF and RPP (P≤0.05). But there was no significant difference between the AIT and ACT in the plasmatic ADM (p>0.05),

Conclusion:

 There is no difference between the effects of interval and continuous training on plasmatic ADM. However, interval training has more effect than continuous training on the improvement of cardiovascular function after CABG surgery.