Assessment of Omeprazole Side effect: A System Biology study

Omeprazole as a proton pump inhibitor has a widespread consumption to inhibit gastric acid secretion. Assessment of omeprazole effects on human cardiovascular system is the main aim of this study.

Gene expression profiles of “human coronary artery endothelial cells” in the absence and presence of omeprazole is downloaded from gene expression omnibus (GEO). The differentially expressed genes (DEGs) are interacted as an interactome and the hub nodes are determined. The DEGs are enriched via gene ontology (GO) analysis. The critical hubs are identified based on GO finding.

Among 103 queried DEGs 61 individuals were included in the main connected component. CTNNB1, HNRNPA1, SRSF4, TRA2A, SFPQ, and RBM5 genes are identified as critical hub genes. Six clusters of biological terms were introduced as deregulated elements in the presence of omeprazole.

In conclusion, long time consumption of omeprazole may be accompanied with undesirable effects, however more evidences are required.