Evaluation of Effects of Resveratrol Consumption on Serum Metabolic Profiles of Diabetes Type 1 Patients, by Using H Nuclear Magnetic Resonance Technique

 Diabetes mellitus type 1 is an autoimmune disease in which the B-cells of the pancreas are damaged, leading to insulin deficiency and finally hyperglycemia. The purpose of this study was to investigate the effect of resveratrol consumption on cellular metabolic pathways in type 1 diabetic patients using proton nuclear magnetic resonance spectroscopy. 

 Thirteen individuals with type 1 diabetes participated in this clinical trial designed as before and after exploratory investigation. All the participants received 500mg capsules of resveratrol twice daily for 60 days. Blood collection was done before resveratrol supplementation, after 30 days, and at the end of 60 days. The data were obtained at three different timings, compared with applying the HNMR spectroscopy. Spectra were processed, and PLS-DA analysis methods were applied to data. Outliers were taken, and the HMDB metabolites databank specified the metabolites and its pathways. 

The main variations identified in this investigation were as follows: short and long-chain fatty acid metabolism, the metabolic pathway of triacylglycerol, 1-propanol, and ethanoic acid, leading to an increase in butyraldehyde and 1-butanol metabolites.

 The results of this research showed a reduction in palmitic acid biosynthesis. This finding suggests that resveratrol may cause significant changes in adipocyte metabolism by inducing adipogenesis and apoptosis in the adipocyte. It may also play a role in improving the production of insulin, leading to low blood glucose levels.