The effect of a course of aerobic-resistance training and ursolic acid consumption on irisin levels and inflammatory factors in overweight middle-aged men

Increasing age and sedentary lifestyle cause physiological obesity. Exercising and using some supplements can improve this condition. The aim of the present study was to evaluate the effect of 12weeks of aerobic-resistance training and complete consumption of ursolic acid on irisin levels and inflammatory factors in overweight middle-aged men.

34 men in the semi-experimental design were randomly divided into three groups of combined exercise-supplement (one)12people, exercise-combination-placebo (two)12people, supplement group (three)10people. The training groups performed 12weeks, three sessions per week, consecutive days-separate aerobic exercises with an intensity of 60 to 75%HRmax and resistance exercises with an intensity of 60 to 75%1RM. Groups two and three received 450 mg of ursolic acid supplement in three meals daily. Blood samples were taken 24hours before the first and 48hours after the last training session.

Irisin levels increased which was significant between groups one and two (P = 0.001) and one and three (P = 0.001) but there was no significant difference between groups two and three. (P = 1). Also, IL6 and CRP levels decreased in three groups, this decrease in IL6 and CRP between groups one and two (P = 0.004), (P = 0.001) and one and three (P =0.004), (P = 0.001) respectively.it was significant but between two and three (P = 0.232), (P = 0.078) was not significant

The results showed that increasing irisin, decreasing inflammatory factors due to aerobic-resistance training and urosolic acid supplementation reduces fat levels and is useful for inactive overweight people.