Serum inflammatory markers in obese mice: Effect of ghrelin

Ghrelin is involved in modulation of food intake and energy homeostasis; however, it may play a role in cardiovascular system and atherosclerosis process. This study aimed to investigate the effect of ghrelin on serum inflammatory markers in control and obese mice.

Ghrelin (100 mg/kg/day, twice daily) was administered interaperitoneally to control and diet‑induced obese mice. After 10 days, blood samples were taken.

Results showed that administration of ghrelin did not change serum hsCRP level; however, it reduced serum IL‑6 concentration in obese mice (P < 0.05).

It seems that the exact role and mechanism of ghrelin in prevention or treatment of atherosclerosis needs more studies.