Electrocatalytic Determination of Anti-Cancer Drug Imatinib, Using Ni Nanoparticle Modified Carbon Paste Electrode

In  this  research,  nickel  nanoparticles  were  synthesized  by  non-aqueous  polyol method  and morphology of nanoparticles was studied using scanning electron microscopy. Then Ni nanoparticle modified carbon paste electrode was prepared. Electrochemical behavior of modified electrode was studied  in  basic  solution,  using  cyclic  voltammetry and  chronoamperometry  methods.  A  pair  of oxidation-reduction  peaks  relating  to  Ni(OH)2/  NiOOH  redox  couple  was  observed  in  cyclic voltammogram of this electrode. Also, the electrochemical behavior of this electrode in presence of imatinib  drug  was  studied.  Results  show  that  this  modified  electrode  has  a  good  ability  for electrocatalytic oxidation of imatinib in basic solution. In presence of imatinib, current intensity of oxidation peak of electrode was increased, depending on its concentration. Linear dynamic range, limit  of  detection  and  rate  constant  of  electrocatalytic  reaction  were  determined  using  cyclic voltammetry  and  chronoamperometry  methods.  Amount  of  limit  of  detection  (LOD)  in  cyclic voltammetry and hydrodynamic amperometry methods were calculated    1.2 × 10 -6 M and 3.5 × 10-7M respectively. Finally, the proposed sensor was successfully applied for determination of imatinib in real samples such as tablet and human blood plasma.