Evaluation of the Antibiotic Susceptibility of Proteus Mirabilis Strains Isolated from Urine Infection

Proteus mirabilis is one of the most common causes of urinary tract infections (UTI) and bacteremia. The aim of this study was to evaluate the antibiotic susceptibility of P. mirabilis strains isolated from urinary tract.

In this cross-sectional study, 60 Proteus mirabilis were obtained from the human urine samples. Detection of strains were performed by standard microbiological and biochemical tests. Antimicrobial susceptibility test was performed by disk diffusion test according to the clinical laboratory sard institute test (CLSI) on the muller hinton agar. Then, multiplex-PCR was achieved for determination flaA and urea genes in the strains by specific oligonucleotides primers.

 All the isolates of P. mirabilis in polymerase chain reaction were showed that flaA and urea genes. The resistance rate was obtained to tobramycin and kanamycin (53%), gentamicin (46%), amikacin (40%), cefotaxime (36%) and ceftriaxone (31%).

According to this study it’s necessary to determine the antibiotic susceptibility of Proteus mirabilis isolated from urinary tract infections in order to provide proper treatment, this will prevent their dissemination and reduce the risk of urinary tract infection complication.